Thyroid Function Test Evaluation in Prostate Cancer Patients in Khartoum State

Abdalla Ali, Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Al Zaiem al Azhari university, Khartoum, Sudan.Follow

Article Type

Original Study

Abstract

Background: Thyroid hormones (TH) are key regulators of essential cellular processes, including proliferation, differentiation, apoptosis, and metabolism. They play an important role in the development of prostate cancer (PCa). Therefore, this study aimed to assess thyroid function tests among PCa patients in Khartoum State. Methods: The study comprised 100 male participants, including 50 PCa patients as a case study and 50 healthy men as the control group. Blood samples were collected for thyroid function test and prostate-specific antigen (PSA) using TosohTM device (China) and enzyme-linked immunosorbent assay (ELISA) using the device FortressTM. Results: Statistical analysis of the test results of the case study demonstrated mean and standard deviation (SD) ± PSA = (31.8 ± 12.5 nmol/l), triiodothyronine (T3) = (3.3 ± 1.3 nmol/l), thyroxine (T4) = (119.58 ± 46.21 nmol/l), and thyroid-stimulating hormone (TSH) = (4.6 ± 3.4 nmol/l). At P-value 0.0001, when compared to the control group, the frequencies among the case study participants for hyperthyroidism, euthyroidism, and hypothyroidism were 33 (66%), 14 (28%), and 3 (6%), respectively. Conclusions: Hyperthyroidism is the most common thyroid disorder among patients with PCa.

Keywords

Prostate cancer (PCa), thyroid hormones (TH) namely T3, T4, TSH, prostate-specific antigen (PSA

Recommended Citation

Ali, Abdalla (2025) "Thyroid Function Test Evaluation in Prostate Cancer Patients in Khartoum State," Iraqi National Journal of Medicine: Vol. 7 : Iss. 1 , Article 4.
Available at: https://doi.org/10.37319/