Histological study on the effect of sildenafil citrate (Viagra) on cerebral hemisphere of adult and aged male Albino rats

Zahraa taboo, Department ᴏf Anatomy , College ᴏf Medicine, University ᴏf Ninevah, Iraq.Follow
Eman Ghanim Sheet, Department of anatomy, college of medicine, university of Nineveh, Mosul, Iraq.Follow
Waleed Kasim, Department ᴏf Anatomy , College ᴏf Medicine, University ᴏf Ninevah, Iraq.Follow

Article Type

Original Study

Abstract

ABSTRACT _x000D_ Objectives: Sildenafil(Viagra) is a known as perfect medications for treatment in patients agony from impotence and pulmonary arterial raised blood pressure, it cause numerous effects on the nervous system by “nitrogen monoxide-cyclic guanosine monophosphate pathway”. The current paper is designed to examine the histostructural variations that may happen in the brain of both adult and elderly male rats after long course duration of Sildenafil(Viagra) drug treatment. Material and Methods: Forty white albino male rats were bought from the veterinary animal house of Mosul University. Twenty of them were between the ages of 3-4 months ( adult ) while the others were between the ages of 22-24 months ( senile ). Grouр I ( 10 adult rats ) and grouр II ( 10 old age rats ) were given distilled water and regarded as control grouрs . Grouр III ( 10 adult rats ) and grouр IV ( 10 old age rats ) were treated with Viagra in a dosage of ten mg. kg. day orally for thirty days. Results: The histological sections from the control adult group showed normal architecture of the frontal lobe cerebral cortex with distinct multipolar neurons , many glial cells and prominent blood vessel while the cerebral cortex of adult rats from treated group showed gliosis with satellitosis (glial cells around neurons)vasogenic and cytogenetic edema with perineuronal vacuolation and vascular congestion., there was mild shrinkage of some neurons Conclusion: Long-lasting administration with sildenafil citrate (Viagra) triggered a noxious outcome on the brain tissues with morphological changes in cells in both adults and the elderly male rats alike, although its effect was greater in the elderly, but this is not attributed to the drug as much as it contributes to the aging process._x000D_

Keywords

Sildenafil, brain, vacuolation, morphological, tissue

Recommended Citation

taboo, Zahraa; Sheet, Eman Ghanim; and Kasim, Waleed (2024) "Histological study on the effect of sildenafil citrate (Viagra) on cerebral hemisphere of adult and aged male Albino rats," Iraqi National Journal of Medicine: Vol. 6 : Iss. 1 , Article 6.
Available at: https://doi.org/10.37319/