Sepsis-Associated Cholestasis: The Impact of Mitochondrial Dysfunction (A Case Report): Sepsis-Associated Cholestasis: The Impact of Mitochondrial Dysfunction (A Case Report)

Behzad Noroozi, Clinical Pharmacy Department, Tehran University of Medical Sciences, Tehran, Iran.Follow
Ali Had, Clinical Pharmacy Department, College of Pharmacy, University of Basra, Basra, Iraq, Iran.Follow
Bita Shahrami, Clinical Pharmacy Department, Tehran University of Medical Sciences, Tehran, Iran.Follow
Ayda Ardabili, Anesthesiology and Intensive Care Department, Tehran University of Medical Sciences, Tehran, Iran.Follow
Fatemeh Yoonesi, Anesthesiology and Intensive Care Department, Tehran University of Medical Sciences, Tehran, Iran.Follow

Article Type

Original Study

Abstract

Introduction: Hyperbilirubinemia – a condition of elevated serum bilirubin above the reference range, is common in hospitalized patients. The reasons for the increase in the bilirubin level can be pre-hepatic, hepatic, and post-hepatic. Sepsis is one of the most important causes of hyperbilirubinemia in critically ill patients._x000D_ Case report: We present a 30-year-old woman with no past medical and drug history who was admitted to the intensive care unit (ICU) due to multiple trauma and fractures due to a fall from height. During the ICU stay, the patient developed jaundice with a high increase in the bilirubin level. A diagnosis of sepsis-associated cholestasis was considered after ruling out other possible pathologies. The hyperbilirubinemia improved with the early management of sepsis concomitant supportive medical therapy._x000D_ Conclusion: Early recognition and treatment of sepsis as a cause of cholestasis should be considered in ICU patients. Drugs targeting mitochondrial function would provide rapid hepatic recovery reducing complications and mortality._x000D_ Keywords: Cholestasis, Critical illness, Hyperbilirubinemia, Liver failure, Sepsis

Keywords

Cholestasis, Critical illness, Hyperbilirubinemia, Liver failure, Sepsis

Recommended Citation

Noroozi, Behzad; Had, Ali; Shahrami, Bita; Ardabili, Ayda; and Yoonesi, Fatemeh (2021) "Sepsis-Associated Cholestasis: The Impact of Mitochondrial Dysfunction (A Case Report): Sepsis-Associated Cholestasis: The Impact of Mitochondrial Dysfunction (A Case Report)," Iraqi National Journal of Medicine: Vol. 3 : Iss. 1 , Article 5.
Available at: https://doi.org/10.37319/iqnjm.3.1.5