Evaluation of VEGF-A in relation to childhood acute lymphoblastic leukemia (in Basrah, Iraq): Evaluation of VEGF-A in relation to childhood acute lymphoblastic leukemia (in Basrah, Iraq)

Zainab Badr, 1B.Sc. Pathological Analysis Techniques, Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq.Follow
Wijdan AL-Moosawi, 2M.B.Ch.B.; Ph.D., Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq.Follow
Sadiq Ali, 3M.B.Ch.B., F.I.B.M.S., Department of Hematopathology, AL-Zahraa College of Medicine, University of Basrah, Basrah, Iraq.Follow

Article Type

Original Study

Abstract

Background: Cancer angiogenesis demonstrates an important role in the progression and pathogenesis of blood malignant disorders including acute lymphoblastic leukemia (ALL). Vascular endothelial growth factor (VEGF)-A is one of the most effective elements of endothelial cell growth; it promotes vascular permeability of endothelial cells and provides the new vasculature with oxygen and nutrients. Higher VEGF-A levels in childhood acute lymphoblastic leukemia (ALL) is associated with poorer patient outcomes._x000D_ Aim of the study: to assess the level of VEGF-A in plasma of children with ALL._x000D_ Subject and method: Forty children with ALL and 40 healthy children as control were enrolled in this study conducted at the Oncology Unit in Basrah Children’s Hospital from Oct 2019 to March 2020. Plasma VEGF-A level was evaluated using ELISA assay._x000D_ Results: The plasma level of VEGF-A is higher in ALL children than those in the control (p < 0.001). Moreover, the plasma VEGF-A level in the high-risk group (HRG) is higher than that in the standard risk group (SRG)._x000D_ Conclusion: The significantly higher level of plasma VEGF-A in ALL children compared to the healthy ones may demonstrate the role of VEGF-A in stimulating angiogenesis in pediatric ALL. _x000D_

Keywords

Angiogenesis, vascular endothelial growth factor-A, childhood acute lymphoblastic leukemia, acute lymphoblastic risk groups

Recommended Citation

Badr, Zainab; AL-Moosawi, Wijdan; and Ali, Sadiq (2021) "Evaluation of VEGF-A in relation to childhood acute lymphoblastic leukemia (in Basrah, Iraq): Evaluation of VEGF-A in relation to childhood acute lymphoblastic leukemia (in Basrah, Iraq)," Iraqi National Journal of Medicine: Vol. 3 : Iss. 1 , Article 4.
Available at: https://doi.org/10.37319/iqnjm.3.1.4